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Morphological and Mechanical Characterization of Self-Assembling Tendon Constructs and Myotendinous Junctions

January 1, 2006


The University of Michigan



There are approximately 33 million patients who sustain musculoskeletal injuries in the United States each year and almost 50 % involve tendon and the other associated soft tissues [33], Direct surgical repair and autologous grafts are the preferred surgical treatments in the majority of cases. However, in many instances, the severity of tissue damage precludes complete repair of the tendon defects. Ideally, a replacement tendon construct would incorporate those properties of native tissue most crucial to their primary role in the transference of force between muscle and bone, namely flexibility and tensile strength along with biological compatibility.




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