May 17, 2020
Sarah Libring, Aparna Shinde, Monica K. Chanda, Maryam Nuru, Heather George, Aya M. Saleh, Ammara Abdullah, Tamara L. Kinzer-Ursem, Sarah Calve, Michael K. Wendt, Luis Solorio
In breast cancer (BC), tissue stiffening via fibronectin (FN) and collagen accumulation is associated with advanced disease progression at both the primary tumor and metastatic sites. H...
May 7, 2020
Alexander R. Ocken, Madeline M. Ku, Tamara L. Kinzer-Ursem and Sarah Calve
Molecular & Cellular Proteomics
Perlecan is a critical proteoglycan found in the extracellular matrix (ECM) of cartilage. In healthy cartilage, perlecan regulates cartilage biomechanics and we...
May 4, 2020
Fan Xu, Donghan Ma, Kathryn P. MacPherson, Sheng Liu, Ye Bu, Yu Wang, Yu Tang, Cheng Bi, Tim Kwok, Alexander A. Chubykin, Peng Yin, Sarah Calve, Gary E. Landreth & Fang Huang
Single-molecule localization microscopy is a powerful tool for visualizing subcellular structures, interactions and protein functions in biological research. However, inhomogeneo...
March 19, 2020
K. P. McCreery, S. Calve and C. P. Neu
Connective Tissue Research
Osteoarthritis (OA) is typically managed in late stages by replacement of the articular cartilage surface with a prosthesis as an effective, though undesirable outcom...
August 26, 2019
A. M. Saleh, K. R. Jacobson, T. L. Kinzer-Ursem and S. Calve
Cellular and Molecular Bioengineering - 2019 Young Innovator Issue
Mapping protein synthesis and turnover during development will provide insight into functional tissue assembly; ho...
May 22, 2019
A. M. Saleh, K. M. Wilding, S. Calve, B. C. Bundy and T. L. Kinzer-Ursem
Journal of Biological Engineering
Metabolic labeling of proteins with non-canonical amino acids (ncAAs) provides unique bioorthogonal chemical groups during de novo synthesis by taking advantag...
March 19, 2019
A. Acuna, S. H. Sofronici, C. J. Goergen and S. Calve
Cells directly interact with the extracellular matrix (ECM) in their microenvironment; however, the mechanical properties of the networks at this scale are not well defin...
March 16, 2019
Roy Lycke, Michael Walls and Sarah Calve
Journal of Biomechanical Engineering
During chondrogenesis, tissue organization changes dramatically. We previously showed that the compressive moduli of chondrocytes increase concomitantly wit...
January 30, 2019
Tanaya Walimbe, Sarah Calve, Alyssa Panitch, M. Preeti Sivasankar
Vocal fold scarring is the fibrotic manifestation of a variety of voice disorders, and is difficult to treat. Tissue engineering therapies provide a potential strategy to reg...
November 19, 2018
Silva Garcia, J.M., Panitch, A. and Calve, S.
Volumetric muscle loss (VML) occurs when skeletal muscle injury is too large for the body to fully self-repair. Typically, fibrotic tissue fills the void, which reduces muscl...
The Dynamic Relationship of Breast Cancer Cells an...
Perlecan knockdown significantly alters extracellu...
Three-dimensional nanoscopy of whole cells and tis...
Atomic Force Microscopy
Collagen Type II
Design of Experiments
Live Cell Imaging
Newly Synthesized Proteins
Permeabilized Muscle Fibers
Skeletal Muscle Progenitor Cells
Superficial Zone Protein
Tendon and Muscle Mechanics
Tibialis Anterior Tendon
cartilage matrix degredration